Posted: Wednesday, May 22, 2024
Efforts to investigate a potential relationship between autoimmune disorders and multiple myeloma have suggested there may be a causal link between primary sclerosing cholangitis and the development of multiple myeloma, according to a study published in Clinical and Experimental Medicine. Additional analyses are warranted to better understand the complexities associated with these two entities, suggested Le He, PhD, of Zhongnan Hospital of Wuhan University, China, and colleagues.
Single nucleotide polymorphisms were collected from various autoimmune diseases including type 1 diabetes (n = 38), rheumatoid arthritis (n = 86), systemic lupus erythematosus (n = 58), psoriasis (n = 90), multiple sclerosis (n = 94), primary sclerosing cholangitis (n = 29), primary biliary cirrhosis (n = 28), and juvenile idiopathic arthritis (n = 21). The investigators used a two-sample Mendelian randomization study to explore the extent of the relationship between the various autoimmune diseases and multiple myeloma.
The study findings revealed a statistically significant correlation between the risk of primary sclerosing cholangitis and multiple myeloma (odds ratio [OR] = 1.0). In addition, the analysis showed nonsignificant positive correlations between multiple myeloma and various autoimmune conditions including type 1 diabetes, systemic lupus erythematosus, psoriasis, multiple sclerosis, and juvenile idiopathic arthritis. A significant negative correlation was found between the risk of rheumatoid arthritis and multiple myeloma (OR = 0.99). However, the Bonferroni correction deemed this relationship to be nonsignificant, according to the study authors. Furthermore, a nonsignificant negative correlation was shown for the risk of primary biliary cirrhosis and multiple myeloma. Moreover, sensitivity assays were performed, which confirmed the accuracy of the study findings.
Disclosure: The study authors reported no conflicts of interest.
Clinical and Experimental Medicine
Resources
For your Patients
