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Joyce F. Liu, MD, MPH
Joyce F. Liu, MD, MPH
Posted: Tuesday, January 21, 2025
Maarten J. Beekman, MD, of The Netherlands Cancer Institute, Amsterdam, and colleagues found no significant long-term association between premenopausal risk-reducing salpingo-oophorectomy and coronary artery calcium, a marker of cardiovascular disease risk. Women undergoing risk-reducing salpingo-oophorectomy before age 45 did not have higher coronary artery calcium scores compared with those undergoing risk-reducing salpingo-oophorectomy after menopause or an external reference group. These findings, published in JACC: CardioOncology, may provide reassurance to patients and clinicians making decisions about the timing of this surgery.
This cross-sectional study included 733 women from a nationwide cohort at high familial risk for ovarian cancer, with subgroups based on the timing of risk-reducing salpingo-oophorectomy. Coronary artery calcium scores were assessed in women aged 60 to 70 years (n = 328); these scores in those who had premenopausal risk-reducing salpingo-oophorectomy (age ≤ 45 years) were compared with those who had postmenopausal risk-reducing salpingo-oophorectomy (age ≥ 54 years). Within the group who had premenopausal surgery (n = 498), the investigators assessed the impact of age at surgery (early, < 41 years, vs late, 41–45 years). And they also compared the premenopausal surgery group with an external reference cohort (n = 5,226).
Multivariable analyses revealed no significant differences in coronary artery calcium prevalence between premenopausal and postmenopausal surgery groups, with relative risks of 0.93 (95% CI = 0.75–1.15) for any coronary artery calcium, 0.71 (95% CI = 0.43–1.17) for moderate coronary artery calcium, and 0.81 (95% CI = 0.30–2.13) for severe coronary artery calcium. Timing within the premenopausal surgery group also showed no significant differences. Moreover, coronary artery calcium scores in the premenopausal group were comparable to those in the external reference cohort.
Disclosure: Dr. Beekman reported no conflicts of interest. For full disclosures of the other study authors, visit www.jacc.org.
