JNCCN 360 - BiomarkerNTRK - Available Clinical Trials

Editors:

Alexander Drilon, MD

Gregory J. Riely, MD, PhD

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Available Clinical Trials

A Study of Alectinib, Entrectinib, Vemurafenib Plus Cobimetinib, or Pralsetinib in Patients With Resectable Stages II-III Non-Small Cell Lung Cancer With ALK, ROS1, NTRK, BRAF V600, or RET Molecular Alterations

A Study to Test the Effect of Larotrectinib in Adults and Children With <em>NTRK</em> Fusion–Positive Solid Tumors (NAVIGATE)

A Study to Test the Safety and Efficacy of Larotrectinib in Treatment of Tumors With <em>NTRK</em> Fusion in Children (SCOUT)

Genetic Testing in Guiding Treatment of Patients With Brain Metastases

Larotrectinib for the Treatment of <em>NTRK</em> Amplification–Positive, Locally Advanced or Metastatic Solid Tumors

Larotrectinib in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With NTRK Fusions (A Pediatric MATCH Treatment Trial)

Real World European Registry of NTRK Fusions and Other Rare Actionable Fusions

Registry for Molecular Testing, Treatment, and Outcome of Patients With Solid Tumors Harboring a NTRK Gene Fusion (REALTRK)

Study to Learn More About the Safety and Effectiveness of the Drug VITRAKVI During Routine Use in Patients With TRK Fusion Cancer Which is Locally Advanced or Spread From the Place Where it Started to Other Places in the Body (ON-TRK)

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