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William J. Gradishar, MD, FACP, FASCO


Nancy Davidson, MD, on Improving Endocrine Therapy for Patients With Breast Cancer

Posted: Friday, March 31, 2023

Nancy Davidson, MD, of the Fred Hutchinson Cancer Research Center, discusses some of the efforts underway to improve endocrine therapy for premenopausal women with breast cancer: the role of ovarian suppression, tamoxifen, and aromatase inhibitors and how to combine these treatments; whether, in some cases, therapy can be de-escalated and still yield equally good outcomes; and whether endocrine therapies can be paired with other modalities such as CDK46 inhibitors. Dr. Davidson also reviews the use of denosumab, which not only improves bone health, but may also improve breast cancer outcomes when given with an aromatase inhibitor for estrogen receptor–positive early-stage disease.

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