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Soo Park, MD
Soo Park, MD
Posted: Monday, April 25, 2022
According to research presented in the International Journal of General Medicine, cutaneous squamous cell carcinoma may be associated with the overexpression of two differentially expressed genes: MYBL2 and TK1. The study used Kyoto Encyclopedia of Genes and Genomes and gene set enrichment analyses to detect relationships between gene expression and this type of skin cancer.
“The pan-cancer analysis showed that these two genes shortened the overall survival time of patients in the majority of cancer types, suggesting that MTBL2 and TK1 may serve as promising prognostic biomarkers and therapeutic targets in the future,” concluded Qiu et al, of Hangzhou Normal University, China.
The study evaluated samples from the Gene Expression Omnibus and noted 179 differentially expressed genes across healthy and skin cancer–positive samples. The investigators used a whole protein-protein interaction network, and the 10 most common hub genes were identified. Each of these hub genes was found to be more significantly expressed in actinic keratosis tissue than in healthy tissue.
When actinic keratosis tissue was compared with cutaneous squamous cell carcinoma tissue, overexpression was noted for a set of six genes. Of those genes, expression of two in particular—MYBL2 and TK1—was significantly higher in tissue with disease invasion than in those without. A relationship was noted between the expression of these two genes and disease initiation and progression. Positive correlations between gene expression and N glycan biosynthesis and p53 signaling pathways were also identified. When the expression of these genes was analyzed relative to all cancers, they were found to have potential pan-cancer prognostic value.
Disclosure: The study authors reported no conflicts of interest.
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