How Does HIV Infection Affect Survival in Patients With Prostate Cancer?
Posted: Thursday, September 5, 2019
Elderly patients who have comorbid human immunodeficiency virus (HIV) and prostate cancer appear to have worse outcomes than patients who are HIV-negative, even after adjusting for the receipt of specific cancer treatments. Anna E. Coghill, PhD, MPH, of the Moffit Cancer Center and Research Institute, in Tampa, Florida, and colleagues published their findings in JAMA Oncology.
“As the HIV population continues to age, the association of HIV infection with poor prostate and breast cancer outcomes will become more important, especially because prostate cancer is projected to become the most common malignancy in the HIV population by 2020,” said Dr. Coghill in an institutional press release. “It is why we are stressing the need for more research on clinical strategies to improve outcomes for HIV-infected patients with cancer.”
Researchers utilized the Surveillance, Epidemiology, and End Results–Medicare linked data to identify 308,268 patients older than age 65 with nonadvanced cancer of the prostate, colorectum, lung, or breast. All of these patients were diagnosed between 1996 and 2012 and had received standard, stage-appropriate cancer treatment.
There were 288 patients in the group who were HIV-positive, and these patients had worse outcomes than their HIV-negative counterparts, after researchers adjusted for differences in treatments. For those with prostate cancer specifically, HIV infections significantly increased the overall mortality rate (hazard ratio = 1.58). Cancer-specific mortality also was elevated for HIV-positive patients with prostate cancer (hazard ratio = 1.65). Additionally, men infected with HIV had significantly higher rates of relapse of disease or death compared with those who were unaffected by HIV (hazard ratio = 1.32).
Disclosure: The study authors reported no conflicts of interest.