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Incidence of Metastatic Cutaneous Squamous Cell Carcinoma in England

By: Kayci Reyer
Posted: Tuesday, December 18, 2018

According to research published in JAMA Dermatology, a population-based study of the incidence of metastatic cutaneous squamous cell carcinoma in England has found a higher risk of development to be associated with being older, white, male, and in lower deprivation quintiles. Changes to the National Cancer Registration and Analysis Service allowed more accurate data analysis of such incidence data.

“This study presents the first national study of the incidence of [metastatic cutaneous squamous cell carcinoma],” concluded Zoë C. Venables, MBChB, of the National Cancer Registration and Analysis Service in London, and colleagues. “With limited health-care resources and an aging population, accurate epidemiologic data are essential for informing future health-care planning, identifying high-risk patients, and evaluating skin cancer prevention policies.”

A total of 76,977 patients diagnosed with cutaneous squamous cell carcinoma between 2013 and 2015 were identified in the study. Among them, the age-standardization rates for the first such registered cases were 77.3 per 100,000 person-years in men and 34.1 per 100,000 person-years in women. An increased tumor count was noted in white male patients of increased age and lower deprivation quintiles. At a maximum follow-up of 36 months, the cumulative incidence of metastatic cutaneous squamous cell carcinoma in patients with a primary cutaneous squamous cell carcinoma was 1.1% for women and 2.4% for men. Primary cutaneous squamous cell carcinomas at the highest risk for metastasis were those located on the ear and on the lip.



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