Thyroid Cancer Coverage from Every Angle

Is a Shift in Neutrophil-to-Lymphocyte Ratio Predictive of Outcomes in Anaplastic Thyroid Cancer?

By: Sarah Campen, PharmD
Posted: Thursday, July 23, 2020

There does not appear to be an association between baseline inflammatory biomarker values and overall survival among patients with anaplastic thyroid cancer, found a retrospective study published in the journal Endocrine. However, Koichi Ito, PhD, of Ito Hospital, Tokyo, and colleagues did identify a worse prognosis in patients with anaplastic thyroid cancer whose neutrophil-to-lymphocyte ratio increased during the follow-up period from their baseline value compared with patients with no such ratio increase.

In this study, the baseline and follow-up complete blood cell count data of 51 patients with anaplastic thyroid cancer were retrospectively analyzed. Patients were assigned to either the increased (n = 27) or non-increased (n = 24) neutrophil-to-lymphocyte ratio group—with a change of neutrophil-to-lymphocyte ratio from baseline to follow-up of more than 5.5 or up to 5.5, respectively.

The researchers detected no significant differences in overall survival, based on baseline neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio values. The median overall survival in patients whose neutrophil-to-lymphocyte ratio had increased during follow-up, however, it was significantly shorter than that for patients without such a ratio increase (7.7 vs. 23.5 months, P < .001) Additionally, in 37 patients who exhibited disease progression during follow-up, the neutrophil-to-lymphocyte ratio was significantly higher after disease progression than at baseline (P < .001).

“Further large-scale studies are needed to clarify the association between inflammatory biomarkers and overall survival or disease progression in anaplastic thyroid cancer,” concluded the authors.

Disclosure: The study authors reported no conflicts of interest.


By continuing to browse this site you permit us and our partners to place identification cookies on your browser and agree to our use of cookies to identify you for marketing. Read our Privacy Policy to learn more.