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Rare Case of Parotid Metastasis 8 Years After Nephrectomy

By: Hope Craig, MSPH
Posted: Monday, January 3, 2022

In a Letter to the Editor published in the journal Oral Oncology, researchers in Brazil highlighted the importance of distinguishing between metastatic and primary tumors in metastatic renal cell carcinoma and primary carcinoma of the salivary glands. Fábio Daumas Nunes, MD, of the University of São Paulo, and colleagues reported a rare case of parotid metastasis of clear cell renal carcinoma that occurred 8 years after nephrectomy.

The patient was a 72-year-old man who presented with swelling in the parotid region. Approximately 8 years earlier, he had undergone radical right nephrectomy for renal cell carcinoma. Otherwise, the patient was well and, aside from swelling, was asymptomatic.

A CT scan and ultrasonography of the left parotid showed a well-defined hyperdense nodule “with lobulated contours (2.0 × 1.4 × 1.8 cm), heterogeneous texture, presenting central and peripheral flow on color Doppler mapping,” the authors wrote. An excision of the lesion and left parotidectomy were performed following fine-needle aspiration biopsy, which revealed a benign salivary gland neoplasm. Following clinical, radiographic, histopathologic, immunohistochemical, and molecular examination, the patient was diagnosed with metastatic clear cell renal cell carcinoma.

“Although uncommon, metastasis should always be regarded when evaluating salivary gland lesions, especially those in major glands. Renal metastasis may develop after a long-time interval, up to 19 years after nephrectomy. Extensive clinical and radiographical investigations are key to diagnosing renal cell carcinoma metastasis,” the authors commented.

Disclosure: The authors reported no conflicts of interest.



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