Posted: Tuesday, January 31, 2023
According to research presented in BMC Urology, a novel approach to surrounding en bloc resection may reduce the likelihood of disease recurrence after transurethral resection of bladder tumor in patients with bladder cancer. The surrounding en bloc transurethral resection of bladder tumor method includes resection via a general bipolar loop electrode as well as simultaneous intravesical chemotherapy delivered while patients are in the postoperative anesthetic period.
“Simultaneous intravesical chemotherapy might increase efficacy and compromise uncomfortability of agents,” noted Lichen Teng, MD, PhD, of Harbin Medical University Cancer Hospital, China, and colleagues.
The single-center, retrospective study included 111 consecutive patients with non–muscle-invasive bladder cancer who received treatment between June 2018 and December 2021. Patients received either conventional transurethral resection of bladder tumor plus immediate intravesical chemotherapy (n = 45) or surrounding en bloc transurethral resection of bladder tumor plus simultaneous intravesical chemotherapy (n = 66). The average follow-up was 24 months.
Patients in the surrounding en bloc group experienced fewer recurrent tumors during follow-up (3% vs. 20%) than did those in the conventional treatment group. Lower urinary tract symptoms were also less common in the surrounding en bloc group (3% vs. 24.4%). No significant differences in clinicopathologic outcomes were observed between the surrounding en bloc and conventional groups. Operative time and procedure-related complications were also similar between the groups.
“We suggest that surrounding en bloc transurethral resection of bladder tumor with simultaneous chemotherapy will be the new standard for treating [non–muscle-invasive bladder cancer] in the future,” concluded the authors.
Disclosure: The study authors reported no conflicts of interest.