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ASCOBT 2023: Can Exercise Improve Quality of Life in Patients on Androgen-Deprivation Therapy?

By: Victoria Kuhr, MS
Posted: Tuesday, August 29, 2023

According to Dennis R. Taaffe, PhD, DSc, MPH, of Edith Cowan University, Joondalup, Australia, different exercise regimens appear to have similar effects on improving the quality of life of patients with prostate cancer who are undergoing androgen-deprivation therapy. Additionally, researchers observed that patients with the lowest quality of life gained the greatest benefits from the exercise programs. These findings were presented at the 2023 American Society of Clinical Oncology (ASCO) Breakthrough meeting (Abstract 72) in Yokohama, Japan.

Patients with prostate cancer were randomly assigned to one of three exercise groups: (1) supervised exercises targeting the musculoskeletal system for 12 months; (2) supervised exercises targeting the cardiovascular system and the muscular systems for 6 months, followed by a 6-month at-home exercise program; or (3) delayed aerobic exercises, with exercise information for 6 months, followed by 6 months of supervised stationary cycling exercise.

A total of 154 patients were included in the study. Of them, 57 were assigned to the first exercise group, 50 to the second exercise group, and 47 to the delayed aerobic group. The patients’ ages ranged from 43 to 90 years. The patients’ mean body mass index was 28.7 kg/m2.

Researchers found no significant differences in quality of life from baseline among the groups. There was a significant group-by-time interaction (P < .05) for physical health after exercising, and the physical health composite score increased at 12 months for groups 2 and 3. There was also a significant time effect (P < .001) for improvements in physical functioning, general health, vitality, and mental health. Additionally, there was a significant time effect for improvements in bodily pain (P = .037), with no between-group differences. Patients in the lowest quartile for quality of life at baseline improved the most with exercise.

Disclosure: The study authors reported no conflicts of interest.

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