Prostate Cancer Coverage from Every Angle

Expert Panel Offers Practical Guide for Managing Castration‐Resistant Prostate Cancer

By: Jenna Carter, PhD
Posted: Tuesday, November 3, 2020

An article published in The Prostate provided recommendations for more efficient ways to treat patients with metastatic castration-resistant prostate cancer. Raoul S. Concepcion MD, FACS, of Vanderbilt University School of Medicine, Nashville, and colleagues formulated a review panel composed of experts in the field who came together to find solutions for specific issues that arise with treatment.

“Confusion abounds within the cancer care community concerning the complex management pathways in advanced prostate cancer…. Thus, there exists a need for practical and relatively concise pathways to guide management,” stated Dr. Concepcion and colleagues. Overall, the panel recommended diagnostic and management options that they found to be most effective in managing the disease. Of note, the authors emphasized their practical guide was not intended to replace national guidelines but rather to complement them.

A total of 14 medical experts included urologists and medical oncologists. The panel members were assigned to four separate working groups, and each group was assigned a specific topic to research, review, and discuss with the entire panel.

After an extensive review of diagnostic and treatment practices, panelists agreed on four major strategies to optimize management of this type of prostate cancer. Their first recommendation was for biomarker monitoring, and the continued use of genetic testing, with germline testing for all patients regardless of castration status. They also recommended that the choice of first‐line treatment be made based on specific clinical characteristics of the disease, with individual recommendations for known drug treatments. Ultimately, they advocated for increased monitoring of adverse events and the use of routine baseline imaging techniques, especially in those presenting with advanced stages of disease.

Disclosure: For full disclosure of the study authors, visit

By continuing to browse this site you permit us and our partners to place identification cookies on your browser and agree to our use of cookies to identify you for marketing. Read our Privacy Policy to learn more.