Multiple Myeloma Coverage from Every Angle
Advertisement
Advertisement

Idecabtagene Vicleucel Under Study in Relapsed and Refractory Multiple Myeloma

By: Sarah Campen, PharmD
Posted: Friday, March 12, 2021

Treatment with idecabtagene vicleucel appears to induce “frequent and deep” responses in patients with triple-class–exposed relapsed and refractory myeloma, according to the results of a pivotal phase II study published in The New England Journal of Medicine. Roughly one-quarter of patients treated with the B-cell maturation antigen–directed chimeric antigen receptor (CAR) T-cell therapy achieved minimal residual disease–negative status.

“The results of this trial represent a true turning point in the treatment of this disease. In my 30 years of treating myeloma, I have not seen any other therapy as effective in this group of patients,” stated initial study author Nikhil C. Munshi, MD, of Dana-Farber Cancer Institute, Boston, in an institutional press release.

The KarMMa trial included 140 patients with disease after at least 3 previous regimens, including a proteasome inhibitor, an immunomodulating agent, and an anti-CD38 antibody. In all, 128 patients received idecabtagene vicleucel at target doses ranging from 150 × 106 to 450 × 106 CAR-positive T cells.

At a median follow-up of 13.3 months, 94 patients (73%) had a response, and 42 (33%) had a complete response or better. Minimal residual disease–negative status (<10−5 nucleated cells) was confirmed in 33 patients; this translated to 26% of all 128 patients who were treated and 79% of the 42 patients who had a complete response or better.

Common toxic effects associated with this immunotherapy included neutropenia in 117 patients (91%), anemia in 89 (70%), and thrombocytopenia in 81 (63%). Cytokine-release syndrome was reported in 107 patients (84%), including 7 (5%) who had events of grade 3 or higher. Almost all patients experienced grade 3 or 4 toxic events.

Disclosure: For full disclosures of the study authors, visit www.nejm.org.



By continuing to browse this site you permit us and our partners to place identification cookies on your browser and agree to our use of cookies to identify you for marketing. Read our Privacy Policy to learn more.