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EMUC 2017: Pulmonary Metastasis in Renal Cell Carcinoma Patients With Pulmonary Nodules

By: Meg Barbor, MPH
Posted: Monday, December 4, 2017

In patients with renal cell carcinoma, the presence of pulmonary nodules—as well as the size and fat invasion of those nodules—is an important risk factor for progression to pulmonary metastasis, according to research presented by Jayoon Ku, MD, of Pusan National University Hospital, Busan, South Korea, and colleagues, at the 2017 European Multidisciplinary Meeting on Urological Cancers (EMUC) in Barcelona (Abstract P114). Thus, the researchers recommend short-term chest radiographic follow-up in these patients.

A total of 1011 patients with renal cell carcinoma enrolled for the study between January 2011 and April 2016. The median follow-up was about 36 months. Of 359 patients who underwent radical nephrectomy and satisfied the criteria for the study, 67 (18.7%) initially presented with pulmonary nodules. Of those 67 patients, 12 (17.9%) experienced progression to pulmonary metastasis after nephrectomy.

For renal cell carcinoma patients with pulmonary nodules, risk factors associated with progression to pulmonary metastasis included the renal tumor size, serum albumin, the largest pulmonary nodule size, the pathologic T stage, and renal fat invasion, the investigators reported.

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