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Advanced Kidney Cancer in Arizona: Are Hispanic and Native Americans at Increased Risk of Mortality?

By: Kayci Reyer
Posted: Tuesday, May 25, 2021

According to research presented in Cancers (Basel), American Indians/Alaska Natives and Hispanic Americans may be at higher risk of developing advanced-stage kidney cancer, and dying of it, than are non-Hispanic White Americans. Ken Batai, PhD, of the University of Arizona Cancer Center, Tucson, and colleagues evaluated data from these population subgroups at the Arizona state and national levels for insight into race-based disparities in treatment and outcomes.

“While we continue to explore differences in kidney cancer surgical treatment across these groups, we are investigating if there are biologic bases in kidney cancer disparities,” commented Dr. Batai in an institutional press release.

Renal cell carcinoma diagnoses between 2004 and 2016 in the National Cancer Database (n = 405,073) and between 2007 and 2016 in the Arizona Cancer Registry (n = 9,337) were analyzed. American Indians/Alaska Natives were at increased risk of developing advanced-stage renal cell carcinoma versus non-Hispanic Whites at both the Arizona state and national levels. Though Hispanic Americans overall were not at increased risk for advanced-stage disease at either level, Mexican Americans and United States–born Mexican Americans were at higher risk. Mexican Americans were 22% more likely to develop advanced-stage disease at the national level and twice as likely at the Arizona state level. In Arizona, United States–born Mexican Americans had a 49.1% advanced-stage disease development rate versus 26.4% in non-Hispanic White Americans. Certain neighborhood factors, such as long distance to health-care facilities and status as an insured person, may have exacerbated or ameliorated these disparities, respectively.

Among Arizonans, United States–born Mexican Americans had the highest risk of disease-specific mortality, followed by Mexican Americans. Hispanic Americans, in general, did not have an increased all-cause mortality risk once models were adjusted to include neighborhood factors. In contrast, American Indian/Alaska Natives were reported to have had an increased risk of all-cause mortality despite adjustment.

Disclosure: The study authors reported no conflicts of interest.



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