Recovery of Long-Term Renal Function After Radical Nephrectomy
Over the long term, a large proportion of patients recover to their preoperative renal function after radical nephrectomy for renal cell carcinoma, according to a multicenter retrospective study published by Paul Russo, MD, FACS, of Memorial Sloan Kettering Cancer Center (MSK), New York, and colleagues, in The Journal of Urology. Additionally, they found that recovery of renal function differs according to preoperative renal function and may be more likely among those with a lower preoperative estimated glomerular filtration rate (eGFR).
The researchers sought to confirm the findings of a previous study of 572 patients from MSK, in which about half of patients recovered to their preoperative eGFR within 2 years after radical nephrectomy for kidney cancer.
The team conducted a retrospective study among 1928 patients from 3 independent centers, and the previous findings were confirmed: 45% of patients in the study recovered to their preoperative eGFR by 2 years after radical nephrectomy. The study also suggested that larger tumor size and female sex may be significantly associated with an increased chance of renal functional recovery.