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Using Hub Genes to Predict Outcomes in Clear Cell Kidney Cancer

By: Sarah Campen, PharmD
Posted: Monday, December 3, 2018

Chinese researchers have identified 15 hub genes that may help predict the prognosis and progression of disease in patients with clear cell renal cell carcinoma. Xinghuan Wang, MD, PhD, of the Zhongnan Hospital of Wuhan University, China, and colleagues believe that integrating these biomarkers into the decision-making process when choosing a treatment plan could hold “crucial clinical significance.” Their findings were published in the Journal of Cellular Physiology.

The researchers used RNA‐sequencing data of patients with clear cell renal cell carcinoma from The Cancer Genome Atlas to identify 2,370 differentially expressed genes. Through analysis, they identified 18 potential hub genes that were significantly related to histologic grade and pathologic stage; after further verification studies, 15 hub genes were selected.

A survival analysis revealed that patients with high expression of each hub gene were more likely to have a poor prognosis than those with low expression for both overall and disease‐free survival. In addition to assisting in the prediction of prognosis, the biomarkers may also differentiate between localized and advanced disease. Ten of the hub genes identified by Dr. Wang and colleagues were consistent with previous studies, and several new hub genes were also discovered.



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