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Does Ferroptosis-Related Gene Portend Poor Prognosis in Kidney Renal Clear Cell Cancer?

By: Vanessa A. Carter, BS
Posted: Monday, June 7, 2021

Yi Wang, PhD, of the Affiliated Hospital of Nantong University, China, and colleagues conducted a bioinformatic analysis using website tools and R scripts to determine the clinicobiologic function and therapeutic potential of the ferroptosis-related gene CHAC1 in kidney renal clear cell carcinoma. These investigators discovered that CHAC1 was downregulated in these samples but upregulated in later-stage and more aggressive kidney carcinoma, suggesting it may be a potential independent risk factor for a poor prognosis. Their results were published in the Journal of Cellular and Molecular Medicine.

The researchers obtained RNA sequencing and pan-cancer sequencing data on 531 kidney renal clear cell carcinoma samples and 73 normal samples from The Cancer Genome Atlas database. Cell lines 786‐0 and CAKI‐1 of kidney renal clear cell carcinoma were collected from patients who received surgical treatment, and renal tubular epithelial cell line HK-2 samples were also obtained.

Compared with normal samples, CHAC1 was found to be upregulated in various carcinomas and lower-grade glioma. Overall, this gene was significantly downregulated in kidney renal clear cell carcinoma yet upregulated in G3 to G4, T3 to T4, and stage III and IV samples. Upregulated CHAC1 was also considered to be associated with higher mortality, according to the investigators.

Multivariate Cox regression analysis determined CHAC1 (P = .014), grade (P = .002), age (P < .001), and stage (P = .001) to be associated with overall survival. CHAC1 influenced the expression of markers of natural killer cells (P < .001), type 1 T-helper cells (P < .05), and memory B cells (P < .05); this gene may also be involved in the expression of checkpoint genes and various gene markers of immune cells. Overexpression of CHAC1 significantly induced cell death but displayed a limited influence in cell invasion and migration.

Disclosure: The study authors reported no conflicts of interest.



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