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Does Lymph Node Ratio Have Prognostic Value in Laryngeal Squamous Cell Cancer?

By: Joseph Fanelli
Posted: Monday, January 7, 2019

Lymph node ratio appears to be a reliable indicator for evaluating the prognosis of patients with laryngeal squamous cell cancer and may be used to increase the prognostic value of traditional tumor-node-metastasis (TNM) staging systems. These findings from China were published in OTO Open, the journal of the American Academy of Otolaryngology–Head and Neck Surgery.

“The risk of [lymph node ratio] was noticeably greater than other factors,” concluded Xinrui Zhang, MD, of the Guangzhou Medical University, and colleagues.

The investigators focused on the records of 229 patients with laryngeal squamous cell cancer who underwent surgery with curative intent with or without adjuvant treatment. They used clinicopathologic parameters of lymph node ratio and log odds ratio as well as univariate and multivariate analyses to evaluate the prognosis of each for overall and disease-free survival.

Dr. Zhang and colleagues found that patients with a high lymph node ratio had a twofold higher risk of recurrence than patients with a low lymph node ratio (26.1% vs. 13.7%). The 5-year overall survival for a patient with a lymph node ratio up to 0.233 and greater than 0.233 was 81.7% and 47.1%, respectively, and the overall survival for log odds ratio up to –0.1 and higher than –0.1 was 79.6% and 51.8%, respectively. Both lymph node ratio and log odds ratio were identified as significant prognostic factors for survival, but the hazard ratio for lymph nodes ratio greater than 0.233 vs. up to 0.233 was 8.95 in overall survival, with a hazard ratio of 11.37 for disease-free survival.

Disclosure: The study authors reported no conflicts of interest.

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