The Hub for Disease-Specific Clinical Information
Advertisement
Advertisement

Can Eicosapentaenoic Acid or Aspirin Prevent Colorectal Adenomas?

By: Cordi Craig
Posted: Monday, March 11, 2019

There appeared to be no difference in the prevention of adenoma among patients with high-risk findings on colonoscopy treated with omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA), aspirin, both, or placebo, according to a U.K. trial, published in The Lancet.  After 1 year, Mark A. Hull, FRCP, of the University of Leeds, United Kingdom, and colleagues found similar adenoma detection rates across all treatment groups.

The double-blind, 2 x 2 factorial trial identified “high-risk” patients during colonoscopy in the English Bowel Cancer Screening Programme. Patients were considered to be at high risk if they had at least 3 adenomas and at least 1 was more than 10 mm in diameter or if they had at least 5 adenomas and they were all less than 10 mm in diameter. The authors randomly assigned patients to receive EPA (n = 179), aspirin (n = 177), both (n = 177), or placebo (n = 176).

The investigators found no difference in the mean number of adenomas per patient across the groups: placebo (1.4), EPA (1.6), aspirin (1.3), or combination therapy (1.0). There was no evidence of a treatment effect between EPA and no EPA (= .81) or aspirin and no aspirin (= .88).

Adverse events occurred in 44% of the placebo group, 46% of the EPA group, 39% of the aspirin group, and 45% of the combination group. Patients treated with EPA experienced more gastrointestinal adverse events (n = 146) than did those who received placebo (n = 85), aspirin (n = 86), and combination therapy (n = 68).

“Further research is needed regarding the effect on colorectal adenoma number according to adenoma type and location,” the authors concluded. “Optimal use of EPA and aspirin might need a precision medicine approach to adenoma recurrence.”

Disclosure:The study authors’ disclosure information may be found at thelancet.com.



By continuing to browse this site you permit us and our partners to place identification cookies on your browser and agree to our use of cookies to identify you for marketing. Read our Privacy Policy to learn more.