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Thomas Flaig, MD


Is Ferroptosis Associated With Bladder Cancer?

By: Julia Fiederlein
Posted: Thursday, March 10, 2022

According to Shankun Zhao, MD, of Taizhou Central Hospital, Zhejiang, China, and colleagues, ferroptosis seems to play a role in the occurrence, development, disease progression, and treatment of bladder cancer. A literature review, which was published in the journal Cancer Cell International, suggested this novel iron-dependent form of nonapoptotic cell death may also be implicated in kidney and prostate cancers.

“Ferroptosis is driven by the declination of scavenging action of GPX4 on reactive oxygen species and the iron-dependent accumulation of reactive oxygen species,” the investigators remarked. “It is difficult to remove cellular reactive oxygen species when the antioxidative capacity of the tumor cells drops significantly, leading to ferroptosis occurrence.”

Using the MEDLINE (PubMed), Cochrane Library, EMBASE (OVID), and PsychINFO databases, the investigators identified two eligible studies reporting the association between ferroptosis and bladder cancer. Based on these data, quinazolinyl-arylurea derivatives and conjugated polymer nanoparticles were found to induce cell death and exert therapeutic effects in bladder cancer via the involvement of ferroptosis.

“At present, experimental and clinical studies that have reported the relationship between ferroptosis and bladder cancer are relatively sparse,” the investigators commented. “Additional well-designed studies are required to explore the underlying molecular mechanisms and clinical outcomes of ferroptosis-mediated therapies for patients with urologic malignancies.”

Disclosure: The study authors reported no conflicts of interest.

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