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Can Oxidative Stress–Related Genes Predict Outcomes for Patients With Bladder Cancer?

By: Joshua D. Madera, MS
Posted: Wednesday, June 15, 2022

The use of an oxidative stress–related gene signature may be useful in predicting overall survival and immune status in patients with bladder cancer, according to a study published in the International Journal of General Medicine. In particular, the use of nomograms may play a key role in predicting overall survival in this patient population, explained Zhanhong Tang, MD, of the First Affiliated Hospital of China Medical University, and colleagues.

“The oxidative stress–related gene signature generated in our study might be associated with immune infiltration, tumor microenvironment, drug sensitivity, and even the efficacy of tumor immunotherapy,” commented the study investigators.

A total of 433 patients with (n = 414) and without (n = 19) bladder cancer were recruited from The Cancer Genome Atlas database. mRNA and clinical data were collected from this patient population. Using the LASSO Cox regression analysis, the study authors designed an oxidative stress–related gene signature.

The study authors revealed a decreased rate of overall survival for patients in the high-risk group as compared with patients in the low-risk group. These findings were further validated by the increased prediction performance determined by the area under the curve. In addition, the risk score was identified as an independent risk factor. Furthermore, an increased predictive value of overall survival was identified using a nomogram that combined tumor-node-metastasis staging with the risk score. Moreover, the role of immune cells and functions in carcinogenesis and development was established based on tumor microenvironment and immune infiltration studies.

Disclosure: For full disclosures of the study authors, visit

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