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Leo I. Gordon, MD, FACP


Is the Endothelial Activation and Stress Index a Potential Prognostic Tool in DLBCL?

By: Kayci Reyer
Posted: Friday, October 28, 2022

Research presented in BMC Cancer suggests that the Endothelial Activation and Stress Index (EASIX) may be a valuable prognostic tool for patients newly diagnosed with diffuse large B-cell lymphoma (DLBCL). An inverse association was observed between EASIX score and treatment outcomes: The higher the score, the worse survival outcomes tended to be.

“Patients with high EASIX values at diagnosis had significantly inferior survival outcomes and showed more severe toxicity than those with low EASIX values,” concluded Gyeong-Won Lee, MD, PhD, of Gyeongsang National University College of Medicine, Jinju, South Korea, and colleagues. “Therefore, EASIX may be a potential predictor of survival outcome in patients with newly diagnosed DLBCL, and its validity should be confirmed through the external validation cohort.”

The study included 265 patients in South Korea who were diagnosed with DLBCL between January 2004 and March 2020. Patients’ serum lactate dehydrogenase levels, creatinine levels, and platelet count measurements were used to determine an EASIX score, and participants were stratified into either the high-score group or the low-score group. The high-score group had lower 1-year overall (63.8%) and progression-free (54.0%) survival rates than the low-score group (84.4% and 79.6%, respectively).

The receiver operating characteristic analysis for overall survival determined the ideal EASIX cutoff score to be 1.33. Slightly more than half of the patients (n = 148; 55.8%) were men. Median patient age was 64 years, and all patients underwent a treatment of cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab.

“The EASIX score is easy to calculate, and any hematology center now has the opportunity to validate EASIX scores in its patient cohort,” the study authors commented. “The EASIX score is a simple score based on three laboratory parameters used worldwide.”

Disclosure: The study authors reported no conflicts of interest.

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