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Risk for Long-Term Complications in Younger Survivors of AML

By: Joseph Cupolo
Posted: Wednesday, February 10, 2021

Researchers from the University of California Davis Comprehensive Cancer Center found that after 10 years of being diagnosed with acute myeloid leukemia (AML), some patients developed endocrine disease (26%), cardiovascular disease (19%), and respiratory disease (7%). The researchers also noted that adolescent and young adult survivors (aged 15–39) who underwent bone marrow transplantation were at least twice as likely to experience most of these late effects. Other late effects were less frequent but included other serious illnesses such as another cancer.

“These late effects were more present among non-White patients and those living in more deprived neighborhoods,” said lead study author Renata Abrahão, MD, MSc, PhD, in a UC Davis Health press release. Hispanic, Black, and Asian/Pacific Islander survivors were at a higher risk of many of the late-effect diseases.

According to the researchers, many factors may lead to the disparities in disease burden. They include differences in therapeutic management, patients’ response to treatment, AML with high-risk mutations, coexisting diseases, and socioeconomic factors. The study, published in the International Journal of Epidemiology, was based upon 1,168 young patients who survived at least 2 years after a diagnosis of AML. Late effects were reported from state hospital discharge data.

“Our findings can help clinicians and policymakers develop better survivorship care plans to reduce suffering and death among adolescent and young adult survivors of AML,” Dr. Abrahão said.

Disclosure: For full disclosures of the study authors, visit academic.oup.com.


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