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Kidney Week 2017: Is There a Link Between End-Stage Renal Disease and Urologic Malignancies?

By: Susan Reckling
Posted: Monday, November 6, 2017

There appears to be a significant association between end-stage renal disease and urologic malignancies, based on the results of a meta-analysis performed by Panagiotis Kompotiatis, MD, of the Mayo Clinic, Rochester, Minnesota, and colleagues. Their findings were presented in New Orleans at Kidney Week 2017 (Abstract TH-PO805), hosted by the American Society of Nephrology.

As the incidence trends of urologic malignancies in patients with end-stage renal disease have remained unclear, the investigators attempted to explore the pooled incidence and incidence trends to determine the risks of such tumors in this patient population. Included in their meta-analysis were 18 observational studies containing 1,872,952 patients with end-stage renal disease.

They found that end-stage renal disease status was linked with a 6.0-fold increased risk of kidney cancer and a 4.4-fold increased risk of urothelial cancer. There appeared to be a positive correlation between the incidence of urologic malignancies in those with end-stage renal disease and the year of the study, although the investigators indicated it was not clear whether the incidence was increasing.