Colorectal Cancer Coverage from Every Angle

ACG 2019: Prevalence of Advanced Polyps in Average-Risk Populations

By: Sarah Campen, PharmD
Posted: Monday, November 4, 2019

For younger adults who are at average risk for colorectal cancer, there are few data regarding the prevalence of advanced adenomas. A study presented at the 2019 American College of Gastroenterology (ACG) Annual Scientific Meeting in San Antonio (oral Abstract 25) found that in the average-risk population, the rate of advanced adenoma increased significantly in those between ages 40 and 44 years old when compared with those younger than age 40. “These data support the latest [American Cancer Society] recommendations to screen average-risk adults at 45 years [of age],” stated study author Lynn Butterly, MD, of Dartmouth-Hitchcock Medical Center in Lebanon, New Hampshire, in an ACG press release.

A total of 42,600 patients were identified using the New Hampshire Colonoscopy Registry and stratified into the following age groups: up to age 40, 40–44, 45–49, 50–54, 55–59, and age 60 and older. Because the goal of the study was to ensure an appropriate “average-risk” population, Dr. Butterly and colleagues excluded higher-risk indications for colonoscopy, such as gastrointestinal bleeding, occult blood, iron deficiency anemia, family history of colorectal cancer, and incomplete exams.

The prevalence of both advanced adenoma and clinically significant serrated polyps in patients between the ages of 45 and 49 was similar to that for patients between the ages of 50 and 54. Older age was associated with a significantly increased risk for adenomas and advanced adenomas. Low-risk symptoms, such as abdominal pain or constipation, did not appear to be associated with an increased risk of colorectal cancer (odds ratio = 1.03).

Disclosure: The author submitted no disclosure information.

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