Fertility Preservation in BRCA-Positive Women With Breast Cancer
By: Susan Reckling
Posted: Thursday, October 19, 2017
In BRCA-positive women with breast cancer, there seems to be a trend for reduced reproductive potential as well as performance of oocyte preservation and ovarian tissue cryopreservation, according to a retrospective analysis of two prospective single-center studies presented at the 2017 European Society for Medical Oncology (ESMO) Congress (Abstract 1541O_PR). Matteo Lambertini, MD, of Institut Jules Bordet and Université Libre de Bruxelles in Belgium, and colleagues conducted this analysis of nearly 100 patients, calling it the largest study addressing fertility issues in this patient population.
Those included in this analysis had BRCA-positive (29 patients) or BRCA-negative (69 patients) breast cancer and underwent oocyte preservation or ovarian tissue cryopreservation. The median age of both groups was about 30 years old.
Patients with BRCA-positive disease tended to retrieve and cryopreserve fewer oocytes than those with BRCA-negative disease. In addition, patients with BRCA-positive disease had numerically lower oocyte density per fragment and per mm2 than did BRCA-negative patients.
“Although no solid conclusion can be drawn from our study because of the small numbers of patients, it does raise awareness about the possible need for personalized approaches for young women with BRCA-mutated breast cancer who are having fertility-preserving procedures before starting anticancer treatment,” commented Dr. Lambertini in an interview with Cancer Network.